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Autotaxin in Fibrosis

Pro-fibrotic processes are also stimulated by autotaxin, a key enzyme that plays a complementary role to calpains in various fibrotic diseases. The enzymatic function of autotaxin generates extracellular lysophosphatidic acid (LPA) which acts via the LPA receptors in tissues to promote the fibrotic processes. Working through an overlapping but complementary process, the autotaxin/LPA pathway also activates myofibroblast cells that play a role in fibrosis.

Increased autotaxin levels and activity are associated with liver, lung, kidney and skin fibrosis, and levels correlate with fibrosis severity in various liver diseases (NAFLD/NASH, viral hepatitis, ALD, cirrhosis). Inhibition of the autotaxin/LPA receptor pathway has been clinically validated in idiopathic pulmonary fibrosis (IPF).

Blade Autotaxin image

References

Wunsch, 2016, Sci Rep. 630847.

Stoddard, 2015, Biomol Ther. 23(1):1.

Potz, 2016, J Nat Sci. 2(9):e218.

Matralis, 2019, Med Res Rev. 39(3):976.

Maher, 2018, Lancet Resp Med. 6(8):627.

Palmer, 2018, Chest. 154(5):1061.

Tager, 2012, Am J Respir Cell Mol Biol. 47(5):563-5.