Research Scientist II

Location: South San Francisco, CA

Blade Therapeutics is advancing novel anti-fibrotic therapies to meet important patient needs in an area that has seen little innovation to date. Several rare/orphan and chronic debilitating conditions manifest as a consequence of fibrosis, a complex, pathologic process in which progressive scarring replaces functional tissue. We are seeking to develop therapies to modify disease progression, and in some cases, potentially reverse the fibrotic damage to tissue. 

Blade is advancing a risk-diversified product portfolio to address various fibrotic diseases and their underlying pathophysiology. The Company has assembled a critical mass of fibrosis expertise and a top-tier leadership team and world-class network of advisors with unparalleled experience in anti-fibrotic drug R&D. Blade’s founding programs are based on the discoveries of Hal Dietz, M.D., Victor A. McKusick Professor of Genetics and Medicine, Johns Hopkins University, whose pioneering research has elucidated a biological pathway that is enabling the discovery of small molecules to treat and potentially reverse fibrosis.

Blade’s objective is to be the leading anti-fibrotic company with a pipeline of novel therapies designed to address the unmet needs for innovative treatments to treat various fibrotic conditions.

Role: Research Scientist II

We are looking for a talented and self-motivated Research Scientist II with broad technical experience in cell and molecular biology. This position will develop in vitro assays with blood cell and other primary human cells, utilizing multiple techniques including high content imaging. The ideal candidate for this position will exhibit not only robust scientific proficiency, but equally strong teamwork, organizational, and communication skills.

The Research Scientist II will report directly to the Executive Vice President Research.

Key Responsibilities

  • Design and conduct experiments for developing and validating pharmacodynamic assays (both human and animal). 
  • Perform in-situ hybridization and immuno-histochemistry techniques.
  • Design, execute, interpret, and troubleshoot quantitative assays in multiple areas in an efficient manner.
  • Write, prepare and present technical data.
  • Support assay development in multiple areas.
  • Apply scientific knowledge, critical thinking, and problem-solving abilities to troubleshoot and refine methods and assays.
  • Effectively communicate results and project status to senior management team.

Professional Experience/Qualifications

  • B.A or Masters degree in molecular / cell biology or related biology degree.
  • 8 + years’ experience in the pharmaceutical / biotechnology industry.
  • Prior experience with determination of protein and mRNA by multiple methodologies. Expertise in high content imaging and fibrosis related in vitro assays is highly preferable.
  • Expertise in development of screening and pharmacodynamic assays.
  • Strategic thinker and problem-solver capable of identifying risks and risk mitigation strategies.
  • Excellent verbal and written communication skills.
  • Ability to multi-task and manage time with minimal supervision.
  • Ability to work independently while effectively interacting and collaborating in a team environment.
  • Must be highly adaptable, flexible, and comfortable working in a high-risk, high-demand, and high-reward biotech environment.
  • Must be well-organized, goal-focused, and detail-oriented.


An attractive compensation and benefits package will be provided.